Impairments of speed and amplitude of movement in Parkinson's disease: A pilot study
Identifieur interne : 002260 ( Main/Exploration ); précédent : 002259; suivant : 002261Impairments of speed and amplitude of movement in Parkinson's disease: A pilot study
Auteurs : Alberto J. Espay [Canada, États-Unis] ; Dorcas E. Beaton [Canada] ; Francesca Morgante [Canada, Italie] ; Carolyn A. Gunraj [Canada] ; Anthony E. Lang [Canada] ; Robert Chen [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Amplitude, Biomechanical Phenomena, Cross-Sectional Studies, Disability Evaluation, Evaluation scale, Female, Humans, Hypokinesia (etiology), Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Pilot Projects, Psychomotor Performance (physiology), Reproducibility of Results, Severity of Illness Index, Speed, Task Performance and Analysis, bradykinesia, unified Parkinson's disease rating scale.
- MESH :
- complications : Parkinson Disease.
- etiology : Hypokinesia.
- physiology : Psychomotor Performance.
- Aged, Aged, 80 and over, Biomechanical Phenomena, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Pilot Projects, Reproducibility of Results, Severity of Illness Index, Task Performance and Analysis.
Abstract
Bradykinesia, characterized by slowness and decreased amplitude of movement, is often considered the most important deficit in Parkinson's disease (PD). The current clinical rating of bradykinesia in PD, based on the motor subscale of the Unified Parkinson's disease Rating Scale (UPDRS‐III), does not individually weigh the impairments in speed and amplitude of rapid alternating movements. We sought to categorize movement in PD to determine whether speed and amplitude have different relationships to current measures of motor impairment and disability. Categories of speed and amplitude (normal, slow/low, and very‐slow/very‐low) were ascertained using an electromagnetic tracking device. Amplitude was disproportionally more affected than speed in the “off” state. UPDRS‐III and the Schwab & England disability scale were worst in patients with very impaired amplitude and best in patients with normal amplitude. A similarly graded relationship was not found for categories of speed impairment. The examiner clinical global impression of change mirrored “off” state amplitude but not speed categories. Levodopa, however, normalized speed to a greater extent than amplitude. Our observations suggest that amplitude and speed impairments may be associated with different functional aspects in PD and deserve separate clinical assessment. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22480
Affiliations:
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Gunraj</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-05-15">2009-05-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1001">1001</biblScope><biblScope unit="page" to="1008">1008</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E78B943017DC4445EA9ED4F232C3C26C3C38391D</idno><idno type="DOI">10.1002/mds.22480</idno><idno type="ArticleID">MDS22480</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Amplitude</term><term>Biomechanical Phenomena</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Evaluation scale</term><term>Female</term><term>Humans</term><term>Hypokinesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pilot Projects</term><term>Psychomotor Performance (physiology)</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Speed</term><term>Task Performance and Analysis</term><term>bradykinesia</term><term>unified Parkinson's disease rating scale</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Biomechanical Phenomena</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Task Performance and Analysis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amplitude</term><term>Echelle d'évaluation</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Vitesse déplacement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bradykinesia, characterized by slowness and decreased amplitude of movement, is often considered the most important deficit in Parkinson's disease (PD). The current clinical rating of bradykinesia in PD, based on the motor subscale of the Unified Parkinson's disease Rating Scale (UPDRS‐III), does not individually weigh the impairments in speed and amplitude of rapid alternating movements. We sought to categorize movement in PD to determine whether speed and amplitude have different relationships to current measures of motor impairment and disability. Categories of speed and amplitude (normal, slow/low, and very‐slow/very‐low) were ascertained using an electromagnetic tracking device. Amplitude was disproportionally more affected than speed in the “off” state. UPDRS‐III and the Schwab & England disability scale were worst in patients with very impaired amplitude and best in patients with normal amplitude. A similarly graded relationship was not found for categories of speed impairment. The examiner clinical global impression of change mirrored “off” state amplitude but not speed categories. Levodopa, however, normalized speed to a greater extent than amplitude. Our observations suggest that amplitude and speed impairments may be associated with different functional aspects in PD and deserve separate clinical assessment. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>États-Unis</li></country><region><li>Ohio</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name></region><name sortKey="Beaton, Dorcas E" sort="Beaton, Dorcas E" uniqKey="Beaton D" first="Dorcas E." last="Beaton">Dorcas E. Beaton</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A." last="Gunraj">Carolyn A. Gunraj</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name></region></country><country name="Italie"><noRegion><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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